SDS-PAGE separation of QP8689 followed by commassie total protein stain results in a primary band consistent with reported data for CD146 / MCAM. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human CD146 / MCAM Protein

$ 448.00$ 1,938.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8689
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 597

Product NumberDescriptionPrice
QP8689-ec-100ug Size: 100 ug, Tag: His $ 398.00
QP8689-ec-1mg Size: 1 mg, Tag: His $ 1,728.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8689-ec-10ug
Recombinant Human CD146 / MCAM Protein General Information
Alternate Names
CD146; MCAM; s-endo; AV025631; CD149; s-gicerin; Muc18; CD146; 1-gicerin
Curated Database and Bioinformatic Data
Gene SymbolMCAM
Entrez Gene ID4162
Ensemble Gene IDENSG00000076706
RefSeq Protein Accession(s)NP_006491.2
RefSeq mRNA Accession(s)NM_006500.2
UniProt ID(s)P43121
UniGene ID(s)Hs.599039
HGNC ID(s)HGNC:6934
COSMIC ID Link(s)MCAM
KEGG Gene ID(s)hsa:4162
PharmGKB ID(s)PA30678
General Description of Recombinant Human CD146 / MCAM Protein.
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elents of the vascular syst, thereby enhancing hatogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during bryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Human CD146 / MCAM Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant CD146 / MCAM based upon sequence from: Human
Host: QP8689 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD146 / MCAM, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8689.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Leu50 - His646
Amino Acid Sequence: LSQSQGNLSH VDWFSVHKEK RTLIFRVRQG QGQSEPGEYE QRLSLQDRGA TLALTQVTPQ DERIFLCQGK RPRSQEYRIQ LRVYKAPEEP NIQVNPLGIP VNSKEPEEVA TCVGRNGYPI PQVIWYKNGR PLKEEKNRVH IQSSQTVESS GLYTLQSILK AQLVKEDKDA QFYCELNYRL PSGNHMKESR EVTVPVFYPT EKVWLEVEPV GMLKEGDRVE IRCLADGNPP PHFSISKQNP STREAEEETT NDNGVLVLEP ARKEHSGRYE CQGLDLDTMI SLLSEPQELL VNYVSDVRVS PAAPERQEGS SLTLTCEAES SQDLEFQWLR EETGQVLERG PVLQLHDLKR EAGGGYRCVA SVPSIPGLNR TQLVNVAIFG PPWMAFKERK VWVKENMVLN LSCEASGHPR PTISWNVNGT ASEQDQDPQR VLSTLNVLVT PELLETGVEC TASNDLGKNT SILFLELVNL TTLTPDSNTT TGLSTSTASP HTRANSTSTE RKLPEPESRG VVIVAVIVCI LVLAVLGAVL YFLYKKGKLP CRRSGKQEIT LPPSRKSELV VEVKSDKLPE EMGLLQGSSG DKRAPGDQGE KYIDLRH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD146 / MCAM Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human CD146 / MCAM Protein