SDS-PAGE separation of QP8716 followed by commassie total protein stain results in a primary band consistent with reported data for Collagen alpha-1(IV) chain. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Collagen alpha-1(IV) chain Protein

$ 148.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8716
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 138

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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8716-ec-10ug
Recombinant Human Collagen alpha-1(IV) chain Protein (30-167aa) General Information
Alternate Names
BSVD; RATOR
Curated Database and Bioinformatic Data
Gene SymbolCOL4A1
Entrez Gene ID1282
Ensemble Gene IDENSG00000187498
RefSeq Protein Accession(s)NP_001290039.1
RefSeq mRNA Accession(s)NM_001303110.1, NM_001845.5
UniProt ID(s)P02462
UniGene ID(s)Hs.17441
HGNC ID(s)HGNC:2202
COSMIC ID Link(s)COL4A1
KEGG Gene ID(s)hsa:1282
PharmGKB ID(s)PA26717
General Description of Recombinant Human Collagen alpha-1(IV) chain Protein (30-167aa).
Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Human Collagen alpha-1(IV) chain Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Collagen alpha-1(IV) chain based upon sequence from: Human
Host: QP8716 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Collagen alpha-1(IV) chain, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8716.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly30 - Pro167
Amino Acid Sequence: GCAGSGCGKC DCHGVKGQKG ERGLPGLQGV IGFPGMQGPE GPQGPPGQKG DTGEPGLPGT KGTRGPPGAS GYPGNPGLPG IPGQDGPPGP PGIPGCNGTK GERGPLGPPG LPGFAGNPGP PGLPGMKGDP GEILGHVP
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Collagen alpha-1(IV) chain Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Collagen alpha-1(IV) chain Protein