SDS-PAGE separation of QP8760 followed by commassie total protein stain results in a primary band consistent with reported data for E3 ubiquitin-protein ligase MIB1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein

$ 398.00$ 1,728.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8760
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 328

Product NumberDescriptionPrice
QP8760-ec-100ug Size: 100 ug, Tag: His $ 398.00
QP8760-ec-1mg Size: 1 mg, Tag: His $ 1,728.00
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On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8760-ec-10ug
Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein General Information
Alternate Names
DIP1; ZZANK2; DIP-1; ZZZ6; MIB; LVNC7
Curated Database and Bioinformatic Data
Gene SymbolMIB1
Entrez Gene ID57534
Ensemble Gene IDENSG00000101752
RefSeq Protein Accession(s)NP_065825.1
RefSeq mRNA Accession(s)NM_020774.3
UniProt ID(s)Q86YT6
UniGene ID(s)Hs.140903
HGNC ID(s)HGNC:21086
COSMIC ID Link(s)MIB1
KEGG Gene ID(s)hsa:57534
PharmGKB ID(s)PA134862722
General Description of Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein.
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis . Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.1 Publication

Human E3 ubiquitin-protein ligase MIB1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant E3 ubiquitin-protein ligase MIB1 based upon sequence from: Human
Host: QP8760 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) E3 ubiquitin-protein ligase MIB1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8760.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Arg5 - Gln332
Amino Acid Sequence: RNNRVMVEGV GARVVRGPDW KWGKQDGGEG HVGTVRSFES PEEVVVVWDN GTAANYRCSG AYDLRILDSA PTGIKHDGTM CDTCRQQPII GIRWKCAECT NYDLCTVCYH GDKHHLRHRF YRITTPGSER VLLESRRKSK KITARGIFAG ARVVRGVDWQ WEDQDGGNGR RGKVTEIQDW SASSPHSAAY VLWDNGAKNL YRVGFEGMSD LKCVQDAKGG SFYRDHCPVL GEQNGNRNPG GLQIGDLVNI DLDLEIVQSL QHGHGGWTDG MFETLTTTGT VCGIDEDHDI VVQYPSGNRW TFNPAVLTKA NIVRSGDAAQ GAEGGTSQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human E3 ubiquitin-protein ligase MIB1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human E3 ubiquitin-protein ligase MIB1 Protein