SDS-PAGE separation of QP8764 followed by commassie total protein stain results in a primary band consistent with reported data for Podocalyxin. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Podocalyxin Protein

$ 88.00$ 1,678.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8764
Species: Human
Available Tags: His
Host: E.coli, Yeast.
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 427

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Shipping Information
4-6 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
SKU: QP8764-ye-10ug
Recombinant Human Podocalyxin Protein General Information
Alternate Names
Podocalyxin; PCLP; PCLP-1; Gp200; PC
Curated Database and Bioinformatic Data
Gene SymbolPODXL
Entrez Gene ID5420
Ensemble Gene IDENSG00000128567
RefSeq Protein Accession(s)NP_001018121.1
RefSeq mRNA Accession(s)NM_001018111.2, NM_005397.3
UniProt ID(s)O00592
UniGene ID(s)Hs.744213
HGNC ID(s)HGNC:9171
COSMIC ID Link(s)PODXL
KEGG Gene ID(s)hsa:5420
PharmGKB ID(s)PA33493
General Description of Recombinant Human Podocalyxin Protein.
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.

Human Podocalyxin Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Podocalyxin based upon sequence from: Human
Host: QP8764 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Podocalyxin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8764.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gln32 - Phe458
Amino Acid Sequence: QNATQTTTDS SNKTAPTPAS SVTIMATDTA QQSTVPTSKA NEILASVKAT TLGVSSDSPG TTTLAQQVSG PVNTTVARGG GSGNPTTTIE SPKSTKSADT TTVATSTATA KPNTTSSQNG AEDTTNSGGK SSHSVTTDLT STKAEHLTTP HPTSPLSPRQ PTSTHPVATP TSSGHDHLMK ISSSSSTVAI PGYTFTSPGM TTTLLETVFH HVSQAGLELL TSGDLPTLAS QSAGITASSV ISQRTQQTSS QMPASSTAPS SQETVQPTSP ATALRTPTLP ETMSSSPTAA STTHRYPKTP SPTVAHESNW AKCEDLETQT QSEKQLVLNL TGNTLCAGGA SDEKLISLIC RAVKATFNPA QDKCGIRLAS VPGSQTVVVK EITIHTKLPA KDVYERLKDK WDELKEAGVS DMKLGDQGPP EEAEDRF
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Podocalyxin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Podocalyxin Protein