SDS-PAGE separation of QP8770 followed by commassie total protein stain results in a primary band consistent with reported data for PSME3 / PA28-gamma. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human PSME3 / PA28-gamma Protein

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SKU: QP8770
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 251

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Datasheets and Documentation
Product Datasheet
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Bioactivity (test results eg. IU/ml):


SKU: QP8770-ec-10ug
Recombinant Human PSME3 / PA28-gamma Protein General Information
Alternate Names
PSME3; PA28-gamma; PA28-gamma; REG-GAMMA; PA28G; PA28gamma; HEL-S-283; Ki
Curated Database and Bioinformatic Data
Gene SymbolPSME3
Entrez Gene ID10197
Ensemble Gene IDENSG00000131467
RefSeq Protein Accession(s)NP_005780.2
RefSeq mRNA Accession(s)NM_005789.3, NM_176863.2
UniProt ID(s)P61289
UniGene ID(s)Hs.152978
HGNC ID(s)HGNC:9570
COSMIC ID Link(s)PSME3
KEGG Gene ID(s)hsa:10197
PharmGKB ID(s)PA33916
General Description of Recombinant Human PSME3 / PA28-gamma Protein.
Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Human PSME3 / PA28-gamma Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant PSME3 / PA28-gamma based upon sequence from: Human
Host: QP8770 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) PSME3 / PA28-gamma, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8770.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ala2 - Thr252
Amino Acid Sequence: ASLLKVDQEV KLKVDSFRER ITSEAEDLVA NFFPKKLLEL DSFLKEPILN IHDLTQIHSD MNLPVPDPIL LTNSHDGLDG PTYKKRRLDE CEEAFQGTKV FVMPNGMLKS NQQLVDIIEK VKPEIRLLIE KCNTVKMWVQ LLIPRIEDGN NFGVSIQEET VAELRTVESE AASYLDQISR YYITRAKLVS KIAKYPHVED YRRTVTEIDE KEYISLRLII SELRNQYVTL HDMILKNIEK IKRPRSSNAE T
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human PSME3 / PA28-gamma Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human PSME3 / PA28-gamma Protein