SDS-PAGE separation of QP8809 followed by commassie total protein stain results in a primary band consistent with reported data for KNG1 / BDK / kininogen-1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human KNG1 / BDK / kininogen-1 Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP8809
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 255

Product Number	Description	Price
QP8809-ec-100ug	Size: 100 ug, Tag: His	$ 398.00
QP8809-ec-1mg	Size: 1 mg, Tag: His	$ 1,728.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8809-ec-10ug

Recombinant Human KNG1 / BDK / kininogen-1 Protein General Information
Alternate Names
KNG1; BDK; Kininogen-1; BDK; BK; KNG
Curated Database and Bioinformatic Data
Gene Symbol	KNG1
Entrez Gene ID	3827
Ensemble Gene ID	ENSG00000113889
RefSeq Protein Accession(s)	NP_000884.1
RefSeq mRNA Accession(s)	NM_000893.3, NM_001102416.2, NM_001166451.1
UniProt ID(s)	P01042
UniGene ID(s)	Hs.77741
HGNC ID(s)	HGNC:6383
COSMIC ID Link(s)	KNG1
KEGG Gene ID(s)	hsa:3827
PharmGKB ID(s)	PA225
General Description of Recombinant Human KNG1 / BDK / kininogen-1 Protein.
1 Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Human KNG1 / BDK / kininogen-1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant KNG1 / BDK / kininogen-1 based upon sequence from: Human

Host: QP8809 protein expressed in E. coli.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) KNG1 / BDK / kininogen-1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8809.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Ser390 - Ser644

Amino Acid Sequence: SSRIGEIKEE TTVSPPHTSM APAQDEERDS GKEQGHTRRH DWGHEKQRKH NLGHGHKHER DQGHGHQRGH GLGHGHEQQH GLGHGHKFKL DDDLEHQGGH VLDHGHKHKH GHGHGKHKNK GKKNGKHNGW KTEHLASSSE DSTTPSAQTQ EKTEGPTPIP SLAKPGVTVT FSDFQDSDLI ATMMPPISPA PIQSDDDWIP DIQIDPNGLS FNPISDFPDT TSPKCPGRPW KSVSEINPTT QMKESYYFDL TDGLS

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human KNG1 / BDK / kininogen-1 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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