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Recombinant Human Smad2 Protein

$ 88.00$ 1,138.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8839
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 466

Product NumberDescriptionPrice
QP8839-ec-10ug Size: 10 ug, Tag: His $ 88.00
QP8839-ec-50ug Size: 50 ug, Tag: His $ 198.00
QP8839-ec-100ug Size: 100 ug, Tag: His $ 268.00
QP8839-ec-200ug Size: 200 ug, Tag: His $ 368.00
QP8839-ec-500ug Size: 500 ug, Tag: His $ 738.00
QP8839-ec-1mg Size: 1 mg, Tag: His $ 1,138.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8839-ec-10ug
Recombinant Human Smad2 Protein General Information
Alternate Names
Smad2; Madh2; Madr2; Smad-2; 7120426M23Rik; mMad2
Curated Database and Bioinformatic Data
Gene SymbolSMAD2
Entrez Gene ID4087
Ensemble Gene IDENSG00000175387
RefSeq Protein Accession(s)NP_001003652.1
RefSeq mRNA Accession(s)NM_001003652.3, NM_005901.5, XM_005258259.3, XM_006722451.3, XM_017025745.1, XM_017025746.1
UniProt ID(s)Q15796
UniGene ID(s)Hs.12253
HGNC ID(s)HGNC:6768
COSMIC ID Link(s)SMAD2
KEGG Gene ID(s)hsa:4087
PharmGKB ID(s)PA134959722
General Description of Recombinant Human Smad2 Protein.
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE elent in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Human Smad2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Smad2 based upon sequence from: Human
Host: QP8839 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Smad2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8839.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Ser2 - Ser467
Amino Acid Sequence: SSILPFTPPV VKRLLGWKKS AGGSGGAGGG EQNGQEEKWC EKAVKSLVKK LKKTGRLDEL EKAITTQNCN TKCVTIPSTC SEIWGLSTPN TIDQWDTTGL YSFSEQTRSL DGRLQVSHRK GLPHVIYCRL WRWPDLHSHH ELKAIENCEY AFNLKKDEVC VNPYHYQRVE TPVLPPVLVP RHTEILTELP PLDDYTHSIP ENTNFPAGIE PQSNYIPETP PPGYISEDGE TSDQQLNQSM DTGSPAELSP TTLSPVNHSL DLQPVTYSEP AFWCSIAYYE LNQRVGETFH ASQPSLTVDG FTDPSNSERF CLGLLSNVNR NATVEMTRRH IGRGVRLYYI GGEVFAECLS DSAIFVQSPN CNQRYGWHPA TVCKIPPGCN LKIFNNQEFA ALLAQSVNQG FEAVYQLTRM CTIRMSFVKG WGAEYRRQTV TSTPCWIELH LNGPLQWLDK VLTQMGSPSV RCSSMS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Smad2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Smad2 Protein