SDS-PAGE separation of QP8886 followed by commassie total protein stain results in a primary band consistent with reported data for Renin-2. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse Renin-2 Protein

$ 578.00$ 2,468.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8886
Species: Mouse
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 288

Product NumberDescriptionPrice
QP8886-ec-100ug Size: 100 ug, Tag: His $ 578.00
QP8886-ec-1mg Size: 1 mg, Tag: His $ 2,468.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8886-ec-10ug
Recombinant Mouse Renin-2 Protein General Information
Alternate Names
Rnr; Ren; Ren-2; Ren-B; Rn-2
Curated Database and Bioinformatic Data
Gene SymbolRen2
Entrez Gene ID19702
RefSeq Protein Accession(s)NP_112470.2
RefSeq mRNA Accession(s)NM_031193.2
UniProt ID(s)P00796
UniGene ID(s)Mm.220955
KEGG Gene ID(s)mmu:19702
General Description of Recombinant Mouse Renin-2 Protein.
Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an increase in secretion of proinflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin

Mouse Renin-2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Renin-2 based upon sequence from: Mouse
Host: QP8886 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Renin-2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8886.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser64 - Asn351
Amino Acid Sequence: SSLTDLISPV VLTNYLNSQY YGEIGIGTPP QTFKVIFDTG SANLWVPSTK CSRLYLACGI HSLYESSDSS SYMENGDDFT IHYGSGRVKG FLSQDSVTVG GITVTQTFGE VTELPLIPFM LAQFDGVLGM GFPAQAVGGV TPVFDHILSQ GVLKEKVFSV YYNRGPHLLG GEVVLGGSDP EHYQGDFHYV SLSKTDSWQI TMKGVSVGSS TLLCEEGCEV VVDTGSSFIS APTSSLKLIM QALGAKEKRL HEYVVSCSQV PTLPDISFNL GGRAYTLSST DYVLQYPN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Renin-2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Mouse Renin-2 Protein