SDS-PAGE separation of QP8902 followed by commassie total protein stain results in a primary band consistent with reported data for Collagenase 3. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Mouse Collagenase 3 Protein

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SKU: QP8902
Species: Mouse
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 368

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Product Datasheet
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SKU: QP8902-ec-10ug
Recombinant Mouse Collagenase 3 Protein General Information
Alternate Names
Clg; MMP-13; Mmp1
Curated Database and Bioinformatic Data
Gene SymbolMMP13
Entrez Gene ID17386
Ensemble Gene IDENSMUSG00000050578
RefSeq Protein Accession(s)NP_032633.1
RefSeq mRNA Accession(s)NM_008607.2
UniProt ID(s)P33435
UniGene ID(s)Mm.5022
COSMIC ID Link(s)MMP13
KEGG Gene ID(s)mmu:17386
General Description of Recombinant Mouse Collagenase 3 Protein.
Plays a role in the degradation of Extracellular domain matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue rodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal bryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.

Mouse Collagenase 3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Collagenase 3 based upon sequence from: Mouse
Host: QP8902 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) Collagenase 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8902.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Tyr105 - Cys472
Amino Acid Sequence: YNVFPRTLKW SQTNLTYRIV NYTPDMSHSE VEKAFRKAFK VWSDVTPLNF TRIYDGTADI MISFGTKEHG DFYPFDGPSG LLAHAFPPGP NYGGDAHFDD DETWTSSSKG YNLFIVAAHE LGHSLGLDHS KDPGALMFPI YTYTGKSHFM LPDDDVQGIQ FLYGPGDEDP NPKHPKTPEK CDPALSLDAI TSLRGETMIF KDRFFWRLHP QQVEAELFLT KSFWPELPNH VDAAYEHPSR DLMFIFRGRK FWALNGYDIL EGYPRKISDL GFPKEVKRLS AAVHFENTGK TLFFSENHVW SYDDVNQTMD KDYPRLIEEE FPGIGNKVDA VYEKNGYIYF FNGPIQFEYS IWSNRIVRVM PTNSILWC
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Collagenase 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Mouse Collagenase 3 Protein