SDS-PAGE separation of QP8921 followed by commassie total protein stain results in a primary band consistent with reported data for Caspase-8. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Caspase-8 Protein

$ 158.00$ 658.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP8921
Species: Human
Available Tags: His
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 263

Product NumberDescriptionPrice
QP8921-ec-10ug Size: 10 ug, Tag: His $ 158.00
QP8921-ec-200ug Size: 200 ug, Tag: His $ 658.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP8921-ec-10ug
Recombinant Human Caspase-8 Protein General Information
Alternate Names
CAP4; MCH5; FLICE; MACH; Casp-8; ALPS2B
Curated Database and Bioinformatic Data
Gene SymbolCASP8
UniProt ID(s)Q14790
COSMIC ID Link(s)CASP8
General Description of Recombinant Human Caspase-8 Protein.
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

Human Caspase-8 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Caspase-8 based upon sequence from: Human
Host: QP8921 protein expressed in E. coli.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Caspase-8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8921.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Ser217 - Asp479
Amino Acid Sequence: SESQTLDKVY QMKSKPRGYC LIINNHNFAK AREKVPKLHS IRDRNGTHLD AGALTTTFEE LHFEIKPHDD CTVEQIYEIL KIYQLMDHSN MDCFICCILS HGDKGIIYGT DGQEAPIYEL TSQFTGLKCP SLAGKPKVFF IQACQGDNYQ KGIPVETDSE EQPYLEMDLS SPQTRYIPDE ADFLLGMATV NNCVSYRNPA EGTWYIQSLC QSLRERCPRG DDILTILTEV NYEVSNKDDK KNMGKQMPQP TFTLRKKLVF PSD
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Caspase-8 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Caspase-8 Protein