Placeholder

Recombinant Human CD40L / CD154 / TNFSF5 Protein

$ 218.00$ 1,458.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9047
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 215

Product NumberDescriptionPrice
QP9047-ye-10ug Size: 10 ug, Tag: His $ 218.00
QP9047-ye-100ug Size: 100 ug, Tag: His $ 528.00
QP9047-ye-500ug Size: 500 ug, Tag: His $ 1,458.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9047-ye-10ug
Recombinant Human CD40L / CD154 / TNFSF5 Protein General Information
Alternate Names
CD40L; CD154; TNFSF5; CD154; IGM; Ly-62; TRAP; Tnlg8b; HIGM1; CD40-L; Cd40l; Ly62; T-BAM; IMD3; Tnfsf5; gp39
Curated Database and Bioinformatic Data
Gene SymbolCD40LG
Entrez Gene ID959
Ensemble Gene IDENSG00000102245
RefSeq Protein Accession(s)NP_000065.1
RefSeq mRNA Accession(s)NM_000074.2
UniProt ID(s)P29965
UniGene ID(s)Hs.592244
HGNC ID(s)HGNC:11935
COSMIC ID Link(s)CD40LG
KEGG Gene ID(s)hsa:959
PharmGKB ID(s)PA36626
General Description of Recombinant Human CD40L / CD154 / TNFSF5 Protein.
Cytokine that binds to CD40/TNFRSF5 (PubMed:1280226). Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

Human CD40L / CD154 / TNFSF5 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant CD40L / CD154 / TNFSF5 based upon sequence from: Human
Host: QP9047 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) CD40L / CD154 / TNFSF5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9047.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: His47 - Leu261
Amino Acid Sequence: HRRLDKIEDE RNLHEDFVFM KTIQRCNTGE RSLSLLNCEE IKSQFEGFVK DIMLNKEETK KENSFEMQKG DQNPQIAAHV ISEASSKTTS VLQWAEKGYY TMSNNLVTLE NGKQLTVKRQ GLYYIYAQVT FCSNREASSQ APFIASLCLK SPGRFERILL RAANTHSSAK PCGQQSIHLG GVFELQPGAS VFVNVTDPSQ VSHGTGFTSF GLLKL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CD40L / CD154 / TNFSF5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

There are no reviews yet.

Be the first to review “Recombinant Human CD40L / CD154 / TNFSF5 Protein”

Your email address will not be published. Required fields are marked *

Share a Protocol (View Reviewed Protocols Below)

Protocol Title

Materials

Methods

Notes


  protocol submission gif
enQuire Bio, LLC   8420 S Continental Divide Rd, #202   Littleton, CO 80127
Chat: See lower right corner. | enquire@enquirebio.com | Fax: 1-720-897-3730
Customer Service Available M-F 8AM-6PM MST or 24/7 Via Email

Recombinant Human CD40L / CD154 / TNFSF5 Protein