SDS-PAGE separation of QP9179 followed by commassie total protein stain results in a primary band consistent with reported data for HMGB1 / HMG1. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human HMGB1 / HMG1 Protein

$ 468.00 – $ 1,298.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP9179
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 214

Product Number	Description	Price
QP9179-ye-100ug	Size: 100 ug, Tag: His	$ 528.00
QP9179-ye-500ug	Size: 500 ug, Tag: His	$ 1,458.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP9179-ye-10ug

Recombinant Human HMGB1 / HMG1 Protein General Information
Alternate Names
HMGB1; HMG1; HMG3; SBP-1; HMG-1; HMG1
Curated Database and Bioinformatic Data
Gene Symbol	Hmgb1
Entrez Gene ID	3146
Ensemble Gene ID	ENSG00000189403
RefSeq Protein Accession(s)	NP_001300821.1
RefSeq mRNA Accession(s)	NM_001313892.1, NM_001313893.1, NM_002128.5
UniProt ID(s)	P09429
UniGene ID(s)	Hs.434102
HGNC ID(s)	HGNC:4983
COSMIC ID Link(s)	HMGB1
KEGG Gene ID(s)	hsa:3146
PharmGKB ID(s)	PA188
General Description of Recombinant Human HMGB1 / HMG1 Protein.
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the Extracellular domain environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the Extracellular domain compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101).

Human HMGB1 / HMG1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant HMGB1 / HMG1 based upon sequence from: Human

Host: QP9179 protein expressed in Yeast.

Tag: His

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) HMGB1 / HMG1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP9179.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Gly2 - Glu215

Amino Acid Sequence: GKGDPKKPRG KMSSYAFFVQ TCREEHKKKH PDASVNFSEF SKKCSERWKT MSAKEKGKFE DMAKADKARY EREMKTYIPP KGETKKKFKD PNAPKRPPSA FFLFCSEYRP KIKGEHPGLS IGDVAKKLGE MWNNTAADDK QPYEKKAAKL KEKYEKDIAA YRAKGKPDAA KKGVVKAEKS KKKKEEEEDE EDEEDEEEEE DEEDEDEEED DDDE

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human HMGB1 / HMG1 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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