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SDS-PAGE separation of QP9247 followed by commassie total protein stain results in a primary band consistent with reported data for LGR5. These data demonstrate Greater than 80% as determined by SDS-PAGE.

Recombinant Human LGR5 Protein

$ 468.00 – $ 1,298.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9247
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 540

Product NumberDescriptionPrice
QP9247-ye-100ug Size: 100 ug, Tag: His $ 468.00
QP9247-ye-500ug Size: 500 ug, Tag: His $ 1,298.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9247-ye-10ug
Recombinant Human LGR5 Protein General Information
Alternate Names
FEX; GPR67; HG38; GPR49; GRP49; Leucine-rich repeat-containing G-protein coupled receptor
Curated Database and Bioinformatic Data
Gene SymbolLGR5
Entrez Gene ID8549
Ensemble Gene IDENSG00000139292
RefSeq Protein Accession(s)NP_001264155.1
RefSeq mRNA Accession(s)NM_001277226.1, NM_001277227.1, NM_003667.3
UniProt ID(s)O75473
UniGene ID(s)Hs.658889
HGNC ID(s)HGNC:4504
COSMIC ID Link(s)LGR5
KEGG Gene ID(s)hsa:8549
PharmGKB ID(s)PA28894
General Description of Recombinant Human LGR5 Protein.
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a st cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by Extracellular domain Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal st cells during postbryonic development.

Human LGR5 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant LGR5 based upon sequence from: Human
Host: QP9247 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) LGR5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9247.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Gly22 - Arg561
Amino Acid Sequence: GSSPRSGVLL RGCPTHCHCE PDGRMLLRVD CSDLGLSELP SNLSVFTSYL DLSMNNISQL LPNPLPSLRF LEELRLAGNA LTYIPKGAFT GLYSLKVLML QNNQLRHVPT EALQNLRSLQ SLRLDANHIS YVPPSCFSGL HSLRHLWLDD NALTEIPVQA FRSLSALQAM TLALNKIHHI PDYAFGNLSS LVVLHLHNNR IHSLGKKCFD GLHSLETLDL NYNNLDEFPT AIRTLSNLKE LGFHSNNIRS IPEKAFVGNP SLITIHFYDN PIQFVGRSAF QHLPELRTLT LNGASQITEF PDLTGTANLE SLTLTGAQIS SLPQTVCNQL PNLQVLDLSY NLLEDLPSFS VCQKLQKIDL RHNEIYEIKV DTFQQLLSLR SLNLAWNKIA IIHPNAFSTL PSLIKLDLSS NLLSSFPITG LHGLTHLKLT GNHALQSLIS SENFPELKVI EMPYAYQCCA FGVCENAYKI SNQWNKGDNS SMDDLHKKDA GMFQAQDERD LEDFLLDFEE DLKALHSVQC SPSPGPFKPC EHLLDGWLIR
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human LGR5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human LGR5 Protein