SDS-PAGE separation of QP9273 followed by commassie total protein stain results in a primary band consistent with reported data for Protein-methionine sulfoxide oxidase MICAL2. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein

$ 528.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9273
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 495

Product NumberDescriptionPrice
QP9273-ye-100ug Size: 100 ug, Tag: His
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On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9273-ye-10ug
Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein General Information
Alternate Names
MICAL-2; MICAL2PV2; MICAL2PV1
Curated Database and Bioinformatic Data
Gene SymbolMICAL2
Entrez Gene ID9645
Ensemble Gene IDENSG00000133816
RefSeq Protein Accession(s)NP_001269592.1
RefSeq mRNA Accession(s)NM_001282663.1, NM_001282664.1, NM_001282665.1, NM_001282666.1, NM_001282667.1, NM_001346292.1, NM_001346293.1, NM_001346294.1, NM_001346295.1, NM_001346296.1, NM_001346297.1, NM_001346298.1, NM_001346299.1, NM_014632.3, XM_017018589.1, XM_017018590.1, XM_017018591.1
UniProt ID(s)O94851
UniGene ID(s)Hs.501928
HGNC ID(s)HGNC:24693
COSMIC ID Link(s)MICAL2
KEGG Gene ID(s)hsa:9645
PharmGKB ID(s)PA142671453
General Description of Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein.
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Human Protein-methionine sulfoxide oxidase MICAL2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Protein-methionine sulfoxide oxidase MICAL2 based upon sequence from: Human
Host: QP9273 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein-methionine sulfoxide oxidase MICAL2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9273.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 - His495
Amino Acid Sequence: MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein-methionine sulfoxide oxidase MICAL2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Protein-methionine sulfoxide oxidase MICAL2 Protein