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Recombinant Human Prestin Protein

$ 468.00$ 1,298.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9401
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 244

Product NumberDescriptionPrice
QP9401-ye-100ug Size: 100 ug, Tag: His $ 468.00
QP9401-ye-500ug Size: 500 ug, Tag: His $ 1,298.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9401-ye-10ug
Recombinant Human Prestin Protein General Information
Alternate Names
PRES; DFNB61
Curated Database and Bioinformatic Data
Gene SymbolSLC26A5
Entrez Gene ID375611
Ensemble Gene IDENSG00000170615
RefSeq Protein Accession(s)NP_001161434.1
RefSeq mRNA Accession(s)NM_001167962.1, NM_001321787.1, NM_198999.2, NM_206883.2, NM_206884.2, NM_206885.2, XM_011516170.2
UniProt ID(s)P58743
UniGene ID(s)Hs.585146
HGNC ID(s)HGNC:9359
COSMIC ID Link(s)SLC26A5
KEGG Gene ID(s)hsa:375611
PharmGKB ID(s)PA33731
General Description of Recombinant Human Prestin Protein.
Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses Cytoplasmic domain anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the mbrane in response to changes in the transmbrane voltage. They move towards the Extracellular domain surface following hyperpolarization, and towards the Cytoplasmic domain side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma mbrane. The area decreases when the anion is near the Cytoplasmic domain face of the mbrane (short state), and increases when the ion has crossed the mbrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the mbrane, but does not allow these anions to dissociate and escape to the Extracellular domain space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site .

Human Prestin Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Prestin based upon sequence from: Human
Host: QP9401 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Prestin, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9401.
Bioactivity Data: Untested
Full Length? Cytoplasmic Domain
Expression Region: Tyr501 - Ala744
Amino Acid Sequence: YRTQSPSYKV LGKLPETDVY IDIDAYEEVK EIPGIKIFQI NAPIYYANSD LYSNALKRKT GVNPAVIMGA RRKAMRKYAK EVGNANMANA TVVKADAEVD GEDATKPEEE DGEVKYPPIV IKSTFPEEMQ RFMPPGDNVH TVILDFTQVN FIDSVGVKTL AGIVKEYGDV GIYVYLAGCS AQVVNDLTRN RFFENPALWE LLFHSIHDAV LGSQLREALA EQEASAPPSQ EDLEPNATPA TPEA
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Prestin Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Prestin Protein