SDS-PAGE separation of QP9439 followed by commassie total protein stain results in a primary band consistent with reported data for Transmembrane protease serine 2. These data demonstrate Greater than 90% as determined by SDS-PAGE.

Recombinant Human Transmembrane protease serine 2 Protein

$ 648.00$ 1,778.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9439
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 387

Product NumberDescriptionPrice
QP9439-ye-100ug Size: 100 ug, Tag: His $ 578.00
QP9439-ye-500ug Size: 500 ug, Tag: His $ 1,588.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9439-ye-10ug
Recombinant Human Transmembrane protease serine 2 Protein General Information
Alternate Names
PP9284; PRSS10
Curated Database and Bioinformatic Data
Gene SymbolTMPRSS2
Entrez Gene ID7113
Ensemble Gene IDENSG00000184012
RefSeq Protein Accession(s)NP_001128571.1
RefSeq mRNA Accession(s)NM_001135099.1, NM_005656.3, XM_011529731.2
UniProt ID(s)O15393
UniGene ID(s)Hs.439309
HGNC ID(s)HGNC:11876
COSMIC ID Link(s)TMPRSS2
KEGG Gene ID(s)hsa:7113
PharmGKB ID(s)PA36577
General Description of Recombinant Human Transmembrane protease serine 2 Protein.
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.

Human Transmembrane protease serine 2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Transmembrane protease serine 2 based upon sequence from: Human
Host: QP9439 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transmembrane protease serine 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9439.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Trp106 - Gly492
Amino Acid Sequence: WKFMGSKCSN SGIECDSSGT CINPSNWCDG VSHCPGGEDE NRCVRLYGPN FILQVYSSQR KSWHPVCQDD WNENYGRAAC RDMGYKNNFY SSQGIVDDSG STSFMKLNTS AGNVDIYKKL YHSDACSSKA VVSLRCIACG VNLNSSRQSR IVGGESALPG AWPWQVSLHV QNVHVCGGSI ITPEWIVTAA HCVEKPLNNP WHWTAFAGIL RQSFMFYGAG YQVEKVISHP NYDSKTKNND IALMKLQKPL TFNDLVKPVC LPNPGMMLQP EQLCWISGWG ATEEKGKTSE VLNAAKVLLI ETQRCNSRYV YDNLITPAMI CAGFLQGNVD SCQGDSGGPL VTSKNNIWWL IGDTSWGSGC AKAYRPGVYG NVMVFTDWIY RQMRADG
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transmembrane protease serine 2 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Transmembrane protease serine 2 Protein