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Recombinant Human Transcriptional coactivator YAP1 Protein

$ 468.00$ 1,298.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9470
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 504

Product NumberDescriptionPrice
QP9470-ye-100ug Size: 100 ug, Tag: His $ 468.00
QP9470-ye-500ug Size: 500 ug, Tag: His $ 1,298.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
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Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

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Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9470-ye-10ug
Recombinant Human Transcriptional coactivator YAP1 Protein General Information
Alternate Names
YKI; COB1; YAP; YAP2; YAP65
Curated Database and Bioinformatic Data
Gene SymbolYAP1
Entrez Gene ID10413
Ensemble Gene IDENSG00000137693
RefSeq Protein Accession(s)NP_001123617.1
RefSeq mRNA Accession(s)NM_001130145.2, NM_001195044.1, NM_001195045.1, NM_001282097.1, NM_001282098.1, NM_001282099.1, NM_001282100.1, NM_001282101.1
UniProt ID(s)P46937
UniGene ID(s)Hs.503692
HGNC ID(s)HGNC:16262
COSMIC ID Link(s)YAP1
KEGG Gene ID(s)hsa:10413
PharmGKB ID(s)PA38103
General Description of Recombinant Human Transcriptional coactivator YAP1 Protein.
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (T) induction. Isoform 2 and isoform 3 can activate the C-terminal fragment (CTF) of ERBB4 (isoform 3).

Human Transcriptional coactivator YAP1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Transcriptional coactivator YAP1 based upon sequence from: Human
Host: QP9470 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Transcriptional coactivator YAP1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9470.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Leu504
Amino Acid Sequence: MDPGQQPPPQ PAPQGQGQPP SQPPQGQGPP SGPGQPAPAA TQAAPQAPPA GHQIVHVRGD SETDLEALFN AVMNPKTANV PQTVPMRLRK LPDSFFKPPE PKSHSRQAST DAGTAGALTP QHVRAHSSPA SLQLGAVSPG TLTPTGVVSG PAATPTAQHL RQSSFEIPDD VPLPAGWEMA KTSSGQRYFL NHIDQTTTWQ DPRKAMLSQM NVTAPTSPPV QQNMMNSASG PLPDGWEQAM TQDGEIYYIN HKNKTTSWLD PRLDPRFAMN QRISQSAPVK QPPPLAPQSP QGGVMGGSNS NQQQQMRLQQ LQMEKERLRL KQQELLRQAM RNINPSTANS PKCQELALRS QLPTLEQDGG TQNPVSSPGM SQELRTMTTN SSDPFLNSGT YHSRDESTDS GLSMSSYSVP RTPDDFLNSV DEMDTGDTIN QSTLPSQQNR FPDYLEAIPG TNVDLGTLEG DGMNIEGEEL MPSLQEALSS DILNDMESVL AATKLDKESF LTWL
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Transcriptional coactivator YAP1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Transcriptional coactivator YAP1 Protein