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Recombinant Human ACVR2B Protein

$ 468.00$ 2,008.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9768
Species: Human
Available Tags: His
Host: Yeast
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 119

Product NumberDescriptionPrice
QP9768-ye-100ug Size: 100 ug, Tag: His $ 468.00
QP9768-ye-1mg Size: 1 mg, Tag: His $ 2,008.00
Shipping Information
On Demand Protein: 3-5 Week Lead Time. (Why?)
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9768-ye-10ug
Recombinant Human ACVR2B Protein General Information
Alternate Names
ACVR2B; ACTRIIB; HTX4; ActR-IIB
Curated Database and Bioinformatic Data
Gene SymbolACVR2B
Entrez Gene ID93
Ensemble Gene IDENSG00000114739
RefSeq Protein Accession(s)NP_001097.2
RefSeq mRNA Accession(s)NM_001106.3
UniProt ID(s)Q13705
UniGene ID(s)Hs.174273
HGNC ID(s)HGNC:174
COSMIC ID Link(s)ACVR2B
KEGG Gene ID(s)hsa:93
PharmGKB ID(s)PA24495
General Description of Recombinant Human ACVR2B Protein.
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, Extracellular domain matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

Human ACVR2B Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant ACVR2B based upon sequence from: Human
Host: QP9768 protein expressed in Yeast.
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) ACVR2B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP9768.
Bioactivity Data: Untested
Full Length? Extracellular Domain
Expression Region: Ser19 - Thr137
Amino Acid Sequence: SGRGEAETRE CIYYNANWEL ERTNQSGLER CEGEQDKRLH CYASWRNSSG TIELVKKGCW LDDFNCYDRQ ECVATEENPQ VYFCCCEGNF CNERFTHLPE AGGPEVTYEP PPTAPTLLT
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human ACVR2B Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human ACVR2B Protein