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Recombinant Human Atypical chemokine receptor 3 Protein

$ 3,478.00
Please Select Product Options Below To View The Catalog Number.

SKU: QP9951
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: Invitro-E.coli
Purity: Greater than 85% as determined by SDS-PAGE.
Length (Amino Acids): 362

Product NumberDescriptionPrice
QP9951-iv-100ug Size: 100 ug, Tag: His-SUMO
Shipping Information
3-4 weeks
Flat Rate Shipping Anywhere in the US: $45
Datasheets and Documentation
Product Datasheet
Certificate of Analysis and Tags (Coming Soon)
Lot Number:

Expiration Date:

Concentration (Write Lyophilized if Lyophilized):

Reconsitution Instructions (Leave Blank if Liquid):

Manufacture Date:

Purity:

Bioactivity (test results eg. IU/ml):


SKU: QP9951-iv-10ug
Recombinant Human Atypical chemokine receptor 3 Protein General Information
Alternate Names
RDC-1; CXC-R7; GPR159; RDC1; CXCR7; CMKOR1; CXCR-7
Curated Database and Bioinformatic Data
Gene SymbolACKR3
Entrez Gene ID57007
Ensemble Gene IDENSG00000144476
RefSeq Protein Accession(s)NP_064707.1
RefSeq mRNA Accession(s)NM_020311.2, XM_005246097.2, XM_005246098.3, XM_017004516.1
UniProt ID(s)P25106
UniGene ID(s)Hs.471751
HGNC ID(s)HGNC:23692
COSMIC ID Link(s)ACKR3
KEGG Gene ID(s)hsa:57007
PharmGKB ID(s)PA162383053
General Description of Recombinant Human Atypical chemokine receptor 3 Protein.
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.

Human Atypical chemokine receptor 3 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Atypical chemokine receptor 3 based upon sequence from Human
Host: QP9951 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Atypical chemokine receptor 3, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP9951.
Bioactivity Data: Untested
Full Length? Full Length Transmembrane Protein
Expression Region: Met1 - Lys362
Amino Acid Sequence: MDLHLFDYSE PGNFSDISWP CNSSDCIVVD TVMCPNMPNK SVLLYTLSFI YIFIFVIGMI ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVLTIPVW VVSLVQHNQW PMGELTCKVT HLIFSINLFG SIFFLTCMSV DRYLSITYFT NTPSSRKKMV RRVVCILVWL LAFCVSLPDT YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVVLG FAVPFSIIAV FYFLLARAIS ASSDQEKHSS RKIIFSYVVV FLVCWLPYHV AVLLDIFSIL HYIPFTCRLE HALFTALHVT QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQS TK
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Atypical chemokine receptor 3 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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Recombinant Human Atypical chemokine receptor 3 Protein