PDF DatasheetHuman Fractalkine / CX3CL1 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Fractalkine / CX3CL1 based upon sequence from: Human
Host: QP5299 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5299.
Bioactivity Data: Human Fractalkine / CX3CL1 induces Human PBMC chemotaxis (significanty different from control at Human Fractalkine / CX3CL1 concentrations greater than 10-100 ng/ml).
Monomer or Dimer: Monomer
Amino Acid Sequence: QHHGVTKCNI TCSKMTSKI P VALLIHYQ QN QASCGKR AII LETRQH RLFC ADPKE QWVKD AMQH LDRQAA ALT RNG
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Fractalkine / CX3CL1 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Fractalkine / CX3CL1 Protein General Information | |
|---|---|
| Alternate Names | |
| Fractalkine, CX3CL1, ABCD-3, C3Xkine, NTT, SCYD1, CXC3, NTN, fractalkine, CXC3C, neurotactin | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CX3CL1 |
| Entrez Gene ID | 6376 |
| Ensemble Gene ID | ENSG00000006210 |
| RefSeq Protein Accession(s) | NP_001291321.1 |
| RefSeq mRNA Accession(s) | NM_001304392.1, NM_002996.4 |
| UniProt ID(s) | P78423 |
| UniGene ID(s) | Hs.531668 |
| HGNC ID(s) | HGNC:10647 |
| COSMIC ID Link(s) | CX3CL1 |
| KEGG Gene ID(s) | hsa:6376 |
| PharmGKB ID(s) | PA35577 |
| General Description of Recombinant Human Fractalkine / CX3CL1 Protein . | |
| Fractalkine, also known as CX3CL1, is a cytokine protein containing a CX3C chemokine motif atop a mucin stalk. Fractalkine is produced by non-hemopoietic cells, including neurons and astrocytes. Soluble fractalkine functions as a chemoattractant for T cells and monocytes. Cell-membrane-bound fractalkine, which is induced on activated endothelial cells, promotes leukocyte adhesion. The transmembrane chemokine receptor CX3CR1 mediates the adhesive and chemoattractant functions of fractalkine. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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