Recombinant Human Estrogen Receptor 2 Protein

$ 88.00 – $ 1,618.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP5999
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His-SUMO
Host: E. coli
Purity: Greater than 90% as determined by SDS-PAGE.
Length (Amino Acids): 322

Product Number	Description	Price
QP5999-ec-10ug	Size: 10 ug, Tag: His-SUMO	$ 88.00
QP5999-ec-50ug	Size: 50 ug, Tag: His-SUMO	$ 218.00
QP5999-ec-100ug	Size: 100 ug, Tag: His-SUMO	$ 348.00
QP5999-ec-200ug	Size: 200 ug, Tag: His-SUMO	$ 568.00
QP5999-ec-500ug	Size: 500 ug, Tag: His-SUMO	$ 988.00
QP5999-ec-1mg	Size: 1 mg, Tag: His-SUMO	$ 1,618.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP5999-ec-10ug

Recombinant Human Estrogen Receptor 2 Protein General Information
Alternate Names
Estrogen Receptor 2, ESR-BETA, NR3A2, ESTRB, Erb, ESRB, ER-BETA
Curated Database and Bioinformatic Data
Gene Symbol	ESR2
Entrez Gene ID	2100
Ensemble Gene ID	ENSG00000140009
RefSeq Protein Accession(s)	NP_001035365.1
RefSeq mRNA Accession(s)	NM_001040275.1, NM_001214902.1, NM_001271876.1, NM_001271877.1, NM_001291712.1, NM_001291723.1, NM_001437.2, XM_017021079.1, XM_017021080.1, XM_017021081.1, XM_017021082.1, XM_017021083.1, XM_017021084.1
UniProt ID(s)	Q92731
UniGene ID(s)	Hs.660607
HGNC ID(s)	HGNC:3468
COSMIC ID Link(s)	ESR2
KEGG Gene ID(s)	hsa:2100
PharmGKB ID(s)	PA27886
General Description of Recombinant Human Estrogen Receptor 2 Protein.
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.

Human Estrogen Receptor 2 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant Estrogen Receptor 2 based upon sequence from Human

Host: QP5999 protein expressed in E. coli.

Tag: His-SUMO

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Estrogen Receptor 2, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.

Application Notes: Please contact us for application specific information for QP5999.

Bioactivity Data: Untested

Full Length? Partial (see sequence information for more details).

Expression Region: Asp2 - Ser323

Amino Acid Sequence: DIKNSPSSLN SPSSYNCSQS ILPLEHGSIY IPSSYVDSHH EYPAMTFYSP AVMNYSIPSN VTNLEGGPGR QTTSPNVLWP TPGHLSPLVV HRQLSHLYAE PQKSPWCEAR SLEHTLPVNR ETLKRKVSGN RCASPVTGPG SKRDAHFCAV CSDYASGYHY GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE VGMVKCGSRR ERCGYRLVRR QRSADEQLHC AGKAKRSGGH APRVRELLLD ALSPEQLVLT LLEAEPPHVL ISRPSAPFTE ASMMMSLTKL ADKELVHMIS WAKKIPGFVE LS

Purity: Greater than 90% as determined by SDS-PAGE.

Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.

Concentration of Human Estrogen Receptor 2 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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