SDS-PAGE separation of QP6711 followed by commassie total protein stain results in a primary band consistent with reported data for Suppressor of cytokine signaling 1. These data demonstrate Greater than 91.1% as determined by SDS-PAGE.
SDS-PAGE separation of QP6711 followed by commassie total protein stain results in a primary band consistent with reported data for Suppressor of cytokine signaling 1. These data demonstrate Greater than 91.1% as determined by SDS-PAGE.

Recombinant Human Suppressor of cytokine signaling 1 Protein

$ 148.00$ 2,008.00
Please Select A Product To View The SKU.

SKU: QP6711
Species: Human
Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Available Tags: His
Host: E.coli, Yeast.
Purity: Greater than 91.1% as determined by SDS-PAGE.
Length (Amino Acids): 211

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Shipping Information
1-2 weeks
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Datasheets and Documentation
Product Datasheet
SKU: QP6711-ec-10ug
Recombinant Human Suppressor of cytokine signaling 1 Protein General Information
Alternate Names
CIS1, CISH1, JAB, SSI1, SOCS-1, SSI-1, TIP3
Curated Database and Bioinformatic Data
Gene SymbolSOCS1
Entrez Gene ID8651
Ensemble Gene IDENSG00000185338
RefSeq Protein Accession(s)NP_003736.1
RefSeq mRNA Accession(s)NM_003745.1
UniProt ID(s)O15524
UniGene ID(s)Hs.50640
HGNC ID(s)HGNC:19383
COSMIC ID Link(s)SOCS1
KEGG Gene ID(s)hsa:8651
PharmGKB ID(s)PA134863068
General Description of Recombinant Human Suppressor of cytokine signaling 1 Protein.
SOCS family proteins form part of a classical negative feedback syst that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival . Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ses to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Human Suppressor of cytokine signaling 1 Recombinant Protein Product Attributes

Product Type: Recombinant Protein
Recombinant Suppressor of cytokine signaling 1 based upon sequence from Human
Host: QP6711 protein expressed in E.coli, Yeast..
Tag: His
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Suppressor of cytokine signaling 1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6711.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 - Ile211
Amino Acid Sequence: MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSPAAPARPR PCPAVPAPAP GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL RDYLSSFPFQ I
Purity: Greater than 91.1% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Suppressor of cytokine signaling 1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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