Recombinant Human IL36G / IL1F9 Protein

$ 398.00 – $ 1,728.00

Please Select Product Options Below To View The Catalog Number.

SKU: QP8125
Species: Human
Available Tags: GST
Host: E. coli
Purity: Greater than 80% as determined by SDS-PAGE.
Length (Amino Acids): 169

Product Number	Description	Price
QP8125-ec-100ug	Size: 100 ug, Tag: GST	$ 398.00
QP8125-ec-1mg	Size: 1 mg, Tag: GST	$ 1,728.00

Shipping Information

On Demand Protein: 3-5 Week Lead Time. (Why?)

Flat Rate Shipping Anywhere in the US: $45

Datasheets and Documentation

Product Datasheet

Certificate of Analysis and Tags (Coming Soon)

SKU: QP8125-ec-10ug

Recombinant Human IL36G / IL1F9 Protein General Information
Alternate Names
IL36G; IL1F9; IL-1RP2; IL-1H1; IL1H1; IL1E; IL1F9; IL1RP2; IL-1F9
Curated Database and Bioinformatic Data
Gene Symbol	IL36G
Entrez Gene ID	56300
Ensemble Gene ID	ENSG00000136688
RefSeq Protein Accession(s)	NP_001265497.1
RefSeq mRNA Accession(s)	NM_001278568.1, NM_019618.3
UniProt ID(s)	Q9NZH8
UniGene ID(s)	Hs.211238
HGNC ID(s)	HGNC:15741
COSMIC ID Link(s)	IL36G
KEGG Gene ID(s)	hsa:56300
PharmGKB ID(s)	PA38395
General Description of Recombinant Human IL36G / IL1F9 Protein.
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.

Human IL36G / IL1F9 Recombinant Protein Product Attributes

Product Type: Recombinant Protein

Recombinant IL36G / IL1F9 based upon sequence from: Human

Host: QP8125 protein expressed in E. coli.

Tag: GST

Protein Construction: A DNA sequence encoding the Homo sapiens (Human) IL36G / IL1F9, was expressed in the hosts and tags indicated. Please select your host/tag option, above.

Application Notes: Please contact us for application specific information for QP8125.

Bioactivity Data: Untested

Full Length? Full Length

Expression Region: Met1 - Asp169

Amino Acid Sequence: MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND

Purity: Greater than 80% as determined by SDS-PAGE.

Reconstitution Instructions:

Concentration of Human IL36G / IL1F9 Protein:

Endotoxin Levels: Not determined.

Buffer: Tris-based buffer, 50% glycerol

Storage Conditions: Store at -20C to -80C.

Limitations and Performance Guarantee

This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.

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