PDF DatasheetHuman Gamma-secretase subunit APH-1A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Gamma-secretase subunit APH-1A based upon sequence from: Human
Host: QP10013 protein expressed in Invitro-E.coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens(Human) Gamma-secretase subunit APH-1A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10013.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – Arg247
Amino Acid Sequence: MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ RSLLCRR
Purity: Greater than 85% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Gamma-secretase subunit APH-1A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Gamma-secretase subunit APH-1A Protein General Information | |
|---|---|
| Alternate Names | |
| 6530402N02Rik; APH-1A; APH-1; CGI-78 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | APH1a |
| Entrez Gene ID | 51107 |
| Ensemble Gene ID | ENSG00000117362 |
| RefSeq Protein Accession(s) | NP_001071096.1 |
| RefSeq mRNA Accession(s) | NM_001077628.2, NM_001243771.1, NM_001243772.1, NM_016022.3 |
| UniProt ID(s) | Q96BI3 |
| UniGene ID(s) | Hs.108408 |
| HGNC ID(s) | HGNC:29509 |
| COSMIC ID Link(s) | APH1a |
| KEGG Gene ID(s) | hsa:51107 |
| PharmGKB ID(s) | PA142672599 |
| General Description of Recombinant Human Gamma-secretase subunit APH-1A Protein. | |
| Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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