PDF DatasheetHuman DNA dC->dU-editing enzyme APOBEC-3A Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant DNA dC->dU-editing enzyme APOBEC-3A based upon sequence from Human
Host: QP5664 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) DNA dC->dU-editing enzyme APOBEC-3A, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5664.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Asn199
Amino Acid Sequence: MEASPASGPR HLMDPHIFTS NFNNGIGRHK TYLCYEVERL DNGTSVKMDQ HRGFLHNQAK NLLCGFYGRH AELRFLDLVP SLQLDPAQIY RVTWFISWSP CFSWGCAGEV RAFLQENTHV RLRIFAARIY DYDPLYKEAL QMLRDAGAQV SIMTYDEFKH CWDTFVDHQG CPFQPWDGLD EHSQALSGRL RAILQNQGN
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human DNA dC->dU-editing enzyme APOBEC-3A Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A Protein General Information | |
|---|---|
| Alternate Names | |
| A3A, ARP3, bK150C2.1, PHRBN | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | APOBEC3A |
| Entrez Gene ID | 100913187 |
| Ensemble Gene ID | ENSG00000128383 |
| RefSeq Protein Accession(s) | NP_001180218.1 |
| RefSeq mRNA Accession(s) | NM_001193289.1, NM_145699.3 |
| UniProt ID(s) | P31941 |
| UniGene ID(s) | Hs.226307 |
| HGNC ID(s) | HGNC:17343 |
| COSMIC ID Link(s) | APOBEC3A |
| KEGG Gene ID(s) | hsa:100913187 |
| PharmGKB ID(s) | PA24891 |
| General Description of Recombinant Human DNA dC->dU-editing enzyme APOBEC-3A Protein. | |
| DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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