PDF DatasheetHuman Ephrin-A1 / EFNA1 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ephrin-A1 / EFNA1 based upon sequence from Human
Host: QP5963 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ephrin-A1 / EFNA1, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP5963.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Asp19 – Ser182
Amino Acid Sequence: DRHTVFWNSS NPKFRNEDYT IHVQLNDYVD IICPHYEDHS VADAAMEQYI LYLVEHEEYQ LCQPQSKDQV RWQCNRPSAK HGPEKLSEKF QRFTPFTLGK EFKEGHSYYY ISKPIHQHED RCLRLKVTVS GKITHSPQAH DNPQEKRLAA DDPEVRVLHS IGHS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ephrin-A1 / EFNA1 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ephrin-A1 / EFNA1 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | EFNA1 |
| Entrez Gene ID | 1942 |
| Ensemble Gene ID | ENSG00000169242 |
| RefSeq Protein Accession(s) | NP_004419.2 |
| RefSeq mRNA Accession(s) | NM_004428.2, NM_182685.1 |
| UniProt ID(s) | P20827 |
| UniGene ID(s) | Hs.516664 |
| HGNC ID(s) | HGNC:3221 |
| COSMIC ID Link(s) | EFNA1 |
| KEGG Gene ID(s) | hsa:1942 |
| PharmGKB ID(s) | PA27656 |
| General Description of Recombinant Human Ephrin-A1 / EFNA1 Protein. | |
| Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assbly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of bryonic neuronal growth cone and regulates dendritic spine morphogenesis. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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