PDF DatasheetHuman Histone H2AX Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Histone H2AX based upon sequence from Human
Host: QP6139 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Histone H2AX, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6139.
Bioactivity Data: Untested
Full Length? Full Length
Amino Acid Sequence: SGRGKTGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGHYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGGV TIAQGGVLPN IQAVLLPKKT SATVGPKAPS GGKKATQASQ EY
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Histone H2AX Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Histone H2AX Protein General Information | |
|---|---|
| Alternate Names | |
| H2A/X, H2A.X, H2AX | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | H2AFX |
| Entrez Gene ID | 3014 |
| Ensemble Gene ID | ENSG00000188486 |
| RefSeq Protein Accession(s) | NP_002096.1 |
| RefSeq mRNA Accession(s) | NM_002105.2 |
| UniProt ID(s) | P16104 |
| UniGene ID(s) | Hs.477879 |
| HGNC ID(s) | HGNC:4739 |
| COSMIC ID Link(s) | H2AFX |
| KEGG Gene ID(s) | hsa:3014 |
| PharmGKB ID(s) | PA29116 |
| General Description of Recombinant Human Histone H2AX Protein. | |
| Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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