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Human Ragulator complex protein LAMTOR5 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Ragulator complex protein LAMTOR5 based upon sequence from Human
Host: QP6147 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Ragulator complex protein LAMTOR5, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Recommended Applications: Immunogen, Protein Standard, Cell culture, or Other Cell Biology Applications.
Application Notes: Please contact us for application specific information for QP6147.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – Ser91
Amino Acid Sequence: MEATLEQHLE DTMKNPSIVG VLCTDSQGLN LGCRGTLSDE HAGVISVLAQ QAAKLTSDPT DIPVVCLESD NGNIMIQKHD GITVAVHKMA S
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions: Concentrated protein in liquid format. Reconstitution is not necessary.
Concentration of Human Ragulator complex protein LAMTOR5 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Ragulator complex protein LAMTOR5 Protein General Information | |
|---|---|
| Alternate Names | |
| HBXIP, XIP | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | HBXIP |
| Entrez Gene ID | 10542 |
| Ensemble Gene ID | ENSG00000134248 |
| RefSeq Protein Accession(s) | NP_006393.2 |
| RefSeq mRNA Accession(s) | NM_006402.2 |
| UniProt ID(s) | O43504 |
| UniGene ID(s) | Hs.439815 |
| HGNC ID(s) | HGNC:17955 |
| COSMIC ID Link(s) | HBXIP |
| KEGG Gene ID(s) | hsa:10542 |
| PharmGKB ID(s) | PA29211 |
| General Description of Recombinant Human Ragulator complex protein LAMTOR5 Protein. | |
| As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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