PDF DatasheetHuman BPHL Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant BPHL based upon sequence from: Human
Isoform: Isoform 2
Host: QP7794 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) BPHL, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7794.
Bioactivity Data: Untested
Full Length? Full Length of Isoform 2
Expression Region: Met1 – Gln274
Amino Acid Sequence: MPRNLLYSLL SSHLSPHFST SVTSAKVAVN GVQLHYQQTG EGDHAVLLLP GMLGSGETDF GPQLKNLNKK LFTVVAWDPR GYGHSRPPDR DFPADFFERD AKDAVDLMKA LKFKKVSLLG WSDGGITALI AAAKYPSYIH KMVIWGANAY VTDEDSMIYE GIRDVSKWSE RTRKPLEALY GYDYFARTCE KWVDGIRQFK HLPDGNICRH LLPRVQCPAL IVHGEKDPLV PRFHADFIHK HVKGSRLHLM PEGKHNLHLR FADEFNKLAE DFLQ
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human BPHL Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human BPHL Protein General Information | |
|---|---|
| Alternate Names | |
| BPHL; BPH-RP; MCNAA; VACVASE | |
| Molecular Weight | |
| Isoform 2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | BPHL |
| Entrez Gene ID | 670 |
| Ensemble Gene ID | ENSG00000137274 |
| RefSeq Protein Accession(s) | NP_001289706.1 |
| RefSeq mRNA Accession(s) | NM_001302777.1, NM_004332.3 |
| UniProt ID(s) | Q86WA6 |
| UniGene ID(s) | Hs.10136 |
| HGNC ID(s) | HGNC:1094 |
| COSMIC ID Link(s) | BPHL |
| KEGG Gene ID(s) | hsa:670 |
| PharmGKB ID(s) | PA25402 |
| General Description of Recombinant Human BPHL Protein. | |
| Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirent for the leaving group other than preferring a primary alcohol. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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