PDF DatasheetHuman Trimethylguanosine synthase Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Trimethylguanosine synthase based upon sequence from: Human
Host: QP7949 protein expressed in E. coli.
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Trimethylguanosine synthase, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP7949.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met713 – Thr853
Amino Acid Sequence: MRVIAIDIDP VKIALARNNA EVYGIADKIE FICGDFLLLA SFLKADVVFL SPPWGGPDYA TAETFDIRTM MSPDGFEIFR LSKKITNNIV YFLPRNADID QVASLAGPGG QVEIEQNFLN NKLKTITAYF GDLIRRPASE T
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Trimethylguanosine synthase Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Trimethylguanosine synthase Protein General Information | |
|---|---|
| Alternate Names | |
| NCOA6IP; PIMT; PIPMT | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | TGS1 |
| Entrez Gene ID | 96764 |
| Ensemble Gene ID | ENSG00000137574 |
| RefSeq Protein Accession(s) | NP_001304831.1 |
| RefSeq mRNA Accession(s) | NM_001317902.1, NM_024831.7 |
| UniProt ID(s) | Q96RS0 |
| UniGene ID(s) | Hs.335068 |
| HGNC ID(s) | HGNC:17843 |
| COSMIC ID Link(s) | TGS1 |
| KEGG Gene ID(s) | hsa:96764 |
| PharmGKB ID(s) | PA162405660 |
| General Description of Recombinant Human Trimethylguanosine synthase Protein. | |
| Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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