PDF DatasheetHuman MIP-3 beta / CCL19 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant MIP-3 beta / CCL19 based upon sequence from: Human
Host: QP8024 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) MIP-3 beta / CCL19, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8024.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Gly22 – Ser98
Amino Acid Sequence: GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKRRSS
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human MIP-3 beta / CCL19 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human MIP-3 beta / CCL19 Protein General Information | |
|---|---|
| Alternate Names | |
| ELC; CKb11; MIP3B; MIP-3b; SCYA19 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL19 |
| Entrez Gene ID | 6363 |
| Ensemble Gene ID | ENSG00000172724 |
| RefSeq Protein Accession(s) | NP_006265.1 |
| RefSeq mRNA Accession(s) | NM_006274.2 |
| UniProt ID(s) | Q99731 |
| UniGene ID(s) | Hs.50002 |
| HGNC ID(s) | HGNC:10617 |
| COSMIC ID Link(s) | CCL19 |
| KEGG Gene ID(s) | hsa:6363 |
| PharmGKB ID(s) | PA35550 |
| General Description of Recombinant Human MIP-3 beta / CCL19 Protein. | |
| May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chokine receptor CCR7. Recombinant CCL19 shows potent chotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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