PDF DatasheetHuman Protein C8orf4 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Protein C8orf4 based upon sequence from: Human
Host: QP8178 protein expressed in E. coli.
Tag: GST
Protein Construction: A DNA sequence encoding the Homo sapiens (Human) Protein C8orf4, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8178.
Bioactivity Data: Untested
Full Length? Full Length
Expression Region: Met1 – His106
Amino Acid Sequence: MKAKRSHQAV IMSTSLRVSP SIHGYHFDTA SRKKAVGNIF ENTDQESLER LFRNSGDKKA EERAKIIFAI DQDVEEKTRA LMALKKRTKD KLFQFLKLRK YSIKVH
Purity: Greater than 80% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Protein C8orf4 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Protein C8orf4 Protein General Information | |
|---|---|
| Alternate Names | |
| TC-1; TC1 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | C8orf4 |
| Entrez Gene ID | 56892 |
| Ensemble Gene ID | ENSG00000176907 |
| RefSeq Protein Accession(s) | NP_064515.1 |
| RefSeq mRNA Accession(s) | NM_020130.4 |
| UniProt ID(s) | Q9NR00 |
| UniGene ID(s) | Hs.591849 |
| HGNC ID(s) | HGNC:1357 |
| COSMIC ID Link(s) | C8orf4 |
| KEGG Gene ID(s) | hsa:56892 |
| PharmGKB ID(s) | PA25962 |
| General Description of Recombinant Human Protein C8orf4 Protein. | |
| Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression. Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown. In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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