PDF DatasheetMouse SIGIRR / TIR8 Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant SIGIRR / TIR8 based upon sequence from: Mouse
Host: QP8219 protein expressed in E.coli, Yeast..
Tag: His-SUMO
Protein Construction: A DNA sequence encoding the Mus musculus (Mouse) SIGIRR / TIR8, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP8219.
Bioactivity Data: Untested
Full Length? Partial (see sequence information for more details).
Expression Region: Met1 – His117
Amino Acid Sequence: MAGVCDMAPN FLSPSEDQAL GLALGREVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS HFSLHEDFWV SANFSEIVSS VLVLNLTNAE DYGTFTCSVW NVSSHSFTLW RAGPAGH
Purity: Greater than 90% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse SIGIRR / TIR8 Protein:
Endotoxin Levels: Not determined.
Buffer: Tris-based buffer, 50% glycerol
Storage Conditions: Store at -20C to -80C.
| Recombinant Mouse SIGIRR / TIR8 Protein General Information | |
|---|---|
| Curated Database and Bioinformatic Data | |
| Gene Symbol | Sigirr |
| Entrez Gene ID | 24058 |
| Ensemble Gene ID | ENSMUSG00000025494 |
| RefSeq Protein Accession(s) | NP_075546.2 |
| RefSeq mRNA Accession(s) | NM_023059.3, XM_006536176.2, XM_006536177.3, XM_006536178.3, XM_006536179.3, XM_006536180.2 |
| UniProt ID(s) | Q9JLZ8 |
| UniGene ID(s) | Mm.38017 |
| COSMIC ID Link(s) | Sigirr |
| KEGG Gene ID(s) | mmu:24058 |
| General Description of Recombinant Mouse SIGIRR / TIR8 Protein. | |
| Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its Extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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