Anti-Bax Antibody Clone 2D2

Observed Subcellular, Organelle Specific Staining Data:

Variations in Bax antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, gallbladder, parathyroid gland, prostate, rectum, small intestine, stomach and thyroid gland, Leydig cells in the testis, macrophages in lung, respiratory epithelial cells in the bronchus and nasopharynx, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. More moderate antibody staining intensity was present in cells in the seminiferous ducts in testis, cells in the tubules in kidney, epidermal cells in the skin, exocrine glandular cells in the pancreas, glandular cells in the adrenal gland, appendix, breast, cervix, uterine, colon, duodenum, endometrium, gallbladder, parathyroid gland, prostate, rectum, small intestine, stomach and thyroid gland, Leydig cells in the testis, macrophages in lung, respiratory epithelial cells in the bronchus and nasopharynx, trophoblastic cells in the placenta and urothelial cells in the urinary bladder. Low, but measureable presence of Bax could be seen inadipocytes in breast and mesenchymal tissue, cells in the endometrial stroma in endometrium, cells in the granular layer in cerebellum, cells in the molecular layer in cerebellum, follicle cells in the ovary, glial cells in the caudate nucleus, cerebral cortex and hippocampus, hepatocytes in liver, Langerhans in skin, lymphoid tissue in appendix, myocytes in skeletal muscle, neuropil in cerebral cortex, non-germinal center cells in the tonsil, ovarian stroma cells in the ovary, peripheral nerve in mesenchymal tissue, peripheral nerve/ganglion in colon, pneumocytes in lung, smooth muscle cells in the smooth muscle and squamous epithelial cells in the vagina. We were unable to detect Bax in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.