PDF DatasheetHuman Anti-CD11c Antibody Product Attributes
Species: Human
Tested Applications: Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-CD11c Antibody Clone: ITGAX/1284
Clone ITGAX/1284 Host and Isotype: Mouse IgG2b
Anti-Human CD11c Positive Control Sample: Human dendritic cells. Human lymph nodes and tonsils.
Cellular Localization of Antibody Cell surface
Buffer and Stabilizer: 10mM PBS with 0.05% BSA and 0.05% Azide
Antibody Concentration: 200 ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant human ITGAX protein fragment (aa 637-827)
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
CD11c Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD11c antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. Low, but measureable presence of CD11c could be seen inhematopoietic cells in the bone marrow, lymphoid tissue in appendix, macrophages in lung and squamous epithelial cells in the tonsil. We were unable to detect CD11c in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD11c General Information | |
|---|---|
| Alternate Names | |
| CD11c, Integrin, alpha X, complement component 3 receptor 4 subunit), ITGAX) | |
| Molecular Weight | |
| 145kDa | |
| Chromosomal Location | |
| 16p11.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | ITGAX |
| Entrez Gene ID | 3687 |
| Ensemble Gene ID | ENSG00000140678 |
| RefSeq Protein Accession(s) | XP_011544156, NP_000878, NP_001273304, XP_011544154 |
| RefSeq mRNA Accession(s) | NM_001286375, NM_000887 XR_950797, XM_011545852, XM_011545854 |
| RefSeq Genomic Accession(s) | NG_011451, NC_000016, NC_018927 |
| UniProt ID(s) | H3BN02, P20702 |
| UniGene ID(s) | H3BN02, P20702 |
| HGNC ID(s) | 6152 |
| Cosmic ID(s) | ITGAX |
| KEGG Gene ID(s) | hsa:3687 |
| PharmGKB ID(s) | PA29952 |
| General Description of CD11c. | |
| Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues. | |
Limitations and Warranty
enQuire Bio’s CD11c Anti-Human Monoclonal is available for Research Use Only. This antibody is guaranteed to work for a period of two years when properly stored.
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