PDF DatasheetHuman Anti-CD20 / MS4A1 Antibody Product Attributes
CD20 / MS4A1 Previously Observed Antibody Staining Patterns
Observed Antibody Staining Data By Tissue Type:
Variations in CD20 / MS4A1 antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. An intense signal was observed in lymphoid tissue in appendix, germinal center cells in the lymph node, cells in the white pulp in spleen, germinal center cells in the tonsil and non-germinal center cells in the tonsil. More moderate antibody staining intensity was present in lymphoid tissue in appendix, germinal center cells in the lymph node, cells in the white pulp in spleen, germinal center cells in the tonsil and non-germinal center cells in the tonsil. Low, but measureable presence of CD20 / MS4A1 could be seen infollicle cells in the ovary and keratinocytes in skin. We were unable to detect CD20 / MS4A1 in other tissues. Disease states, inflammation, and other physiological changes can have a substantial impact on antibody staining patterns. These measurements were all taken in tissues deemed normal or from patients without known disease.
| CD20 / MS4A1 General Information | |
|---|---|
| Alternate Names | |
| B-lymphocyte antigen CD20, CD20, Cluster of Differentiation 20 | |
| Molecular Weight | |
| 33-37kDa | |
| Chromosomal Location | |
| 11q12.2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | MS4A1 |
| Entrez Gene ID | 931 |
| Ensemble Gene ID | ENSG00000156738 |
| RefSeq Protein Accession(s) | NP_068769, NP_690605 |
| RefSeq mRNA Accession(s) | NM_152866, NM_021950 |
| RefSeq Genomic Accession(s) | NG_023388, NC_018922, NC_000011 |
| UniProt ID(s) | P11836, A0A024R507 |
| UniGene ID(s) | P11836, A0A024R507 |
| HGNC ID(s) | 7315 |
| Cosmic ID(s) | MS4A1 |
| KEGG Gene ID(s) | hsa:931 |
| PharmGKB ID(s) | PA31111 |
| General Description of CD20 / MS4A1. | |
| Recognizes a protein of 30-33kDa, which is identified as CD20. It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. This MAb can be used for immunophenotyping of leukemia and malignant cells, B lymphocyte detection in peripheral blood and B cell localization in tissues. It reacts with the majority of B-cells present in peripheral blood and lymphoid tissues and their derived lymphomas. In lymphoid tissue, germinal center blasts and B-immunoblasts are particularly reactive. It is a reliable antibody for ascribing a B-cell phenotype in known lymphoid tissues. Rarely, CD20-positive T-cell lymphomas have been reported. Reactivity has also been noted with Reed-Sternberg cells in cases of Hodgkin s disease, particularly of lymphocyte predominant type. | |
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