PDF DatasheetHuman ;Mouse ;Rat ;Cow Anti-S100A1 Antibody Product Attributes
Species: Human ;Mouse ;Rat ;Cow
Cross Reactivity:
Tested Applications: Flow Cytometry, Immunofluorescence, Western Blot, Immunohistochemistry (IHC).
Clonality: Monoclonal
Anti-S100A1 Antibody Clone: S100A1/1012
Clone S100A1/1012 Host and Isotype: Mouse IgG2a, kappa
Anti-Human ;Mouse ;Rat ;Cow S100A1 Positive Control Sample: Brain, Melanoma
Cellular Localization of Antibody <S100A1/1012 Staining: Cytoplasmic
Buffer and Stabilizer: 10mM PBS with 0.05% BSA & 0.05% azide.
Antibody Concentration: 200ug/ml
Antibody Purification Method:Protein A/G Purified
Immunogen: Recombinant full-length human S100A1 protein
Storage Conditions: Store at 2 to 8° C (refrigerate). Stable for 24 months when properly stored.
S100A1 Previously Observed Antibody Staining Patterns
| S100A1 General Information | |
|---|---|
| Alternate Names | |
| Molecular Weight | |
| 10-12kDa | |
| Chromosomal Location | |
| 1q21.3 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | S100A1 |
| Entrez Gene ID | 6271 |
| UniProt ID(s) | P23297 |
| General Description of S100A1. | |
| The family of EF-hand type Ca2+-binding proteins includes calbindin, S-100 alpha, beta, calgranulins, B, C,, the parvalbumin family members, including parvalbumin alpha, parvalbumin beta. The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression, differentiation. S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain, S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of two alpha chains, two beta chains or one alpha, one beta chain. S-100 localizes to the cytoplasm, nuclei of astrocytes, Schwann s cells, ependymomas, astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours, in Langerhans cells in the skin. Calbindin, S-100 proteins, parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha, beta are present in a variety of other tissues, calbindin is present in intestine, kidney. | |
Limitations and Warranty
This product is for Research Use Only. This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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