PDF DatasheetHuman Beta Defensin 103AB Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Beta Defensin 103AB based upon sequence from: Human
Host: QP5323 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Immunogen, Protein Standard, Other Cell Biology Applications
Application Notes: Please contact us for application specific information for QP5323.
Bioactivity Data: Untested
Monomer or Dimer: Monomer
Amino Acid Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Beta Defensin 103AB Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Beta Defensin 103AB Protein General Information | |
|---|---|
| Alternate Names | |
| DEFB103A, DEFB103B, Beta Defensin a/b | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | DEFB103AB |
| Entrez Gene ID | 414325 |
| Ensemble Gene ID | ENSG00000176797 |
| RefSeq Protein Accession(s) | NP_001075020.1 |
| RefSeq mRNA Accession(s) | NM_001081551.3, NM_018661.4, XM_017030192.1 |
| UniProt ID(s) | P81534 |
| UniGene ID(s) | Hs.283082 |
| HGNC ID(s) | HGNC:15967 |
| KEGG Gene ID(s) | hsa:414325 |
| PharmGKB ID(s) | PA134933952 |
| General Description of Recombinant Human Beta Defensin 103AB Protein . | |
| Beta-Defensin 3 (BD-3), also known as DEFB-3, is a member of the defensin class of antimicrobial peptides. Beta defensins exert host defense responses against viruses, bacteria, and fungi through the binding and permeabilizing of microbial membranes. BD-3 expression is stimulated by interferon-gamma and is an important molecule during adaptive immunity. BD-3 functions to activate monocytes and mast cells, and has antibacterial functions towards Gram-negative and Gram-positive bacteria. Further, BD-3 blocks human immunodeficiency virus type 1 (HIV-1) replication through the downregulation of the HIV-1 co-receptor, CXCR4. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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