PDF DatasheetHuman CCL8 / MCP-2 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant CCL8 / MCP-2 based upon sequence from: Human
Host: QP5251 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5251.
Bioactivity Data: Human CCL8 / MCP-2 induces Human THP-1 chemotaxis (significanty different from control at Human CCL8 / MCP-2 concentrations greater than 100 ng/ml).
Monomer or Dimer: Monomer
Amino Acid Sequence: QPDSVSIPIT CCFNVINRKI PIQRLESYTR ITNIQCPKEA VIFKTKRGKE VCADPKERWV RDSMKHLDQI FQNLKP
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human CCL8 / MCP-2 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human CCL8 / MCP-2 Protein General Information | |
|---|---|
| Alternate Names | |
| CCL8, MCP-2, AB023418, Scya8, Mcp2, HC14, MCP-2, 1810063B20Rik | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | CCL8 |
| Entrez Gene ID | 6355 |
| Ensemble Gene ID | ENSG00000108700 |
| RefSeq Protein Accession(s) | NP_005614.2 |
| RefSeq mRNA Accession(s) | NM_005623.2 |
| UniProt ID(s) | P80075 |
| UniGene ID(s) | Hs.271387 |
| HGNC ID(s) | HGNC:10635 |
| COSMIC ID Link(s) | CCL8 |
| KEGG Gene ID(s) | hsa:6355 |
| PharmGKB ID(s) | PA35567 |
| General Description of Recombinant Human CCL8 / MCP-2 Protein . | |
| Monocyte chemotactic protein 2 (MCP-2), also known as CCL8, is a cytokine that is important during allergic and inflammatory responses. MCP-2 activates mast cells, eosinophils, and basophils through the G protein-coupled chemokine receptors CCR1, CCR2B, and CCR5. MCP-2 signaling through the CCR5 receptor also functions as a natural inhibitor of the human immunodeficiency virus, type 1 (HIV-1). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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