PDF DatasheetHuman Follistatin / FST Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Follistatin / FST based upon sequence from: Human
Host: QP5355 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5355.
Bioactivity Data: Neutralization of Human Activin A induced cytotoxicity of MPC-11 cells was significantly induced by less than 200 ng/ml of Human Follistatin / FST (minimum activity of at least 5.0 x 10^3 units/mg).
Monomer or Dimer: Monomer
Amino Acid Sequence: MGNCWLRQAK NGRCQVLYK T ELSKEECC ST GRLSTSW TEE DVNDNT LFKW MIFNG GAPNC IPCK ETCENV DCG PGKKCRMNKK NKPRCVC AP DCSNITWK G PVCGLDGKT YRNECALLKA RCKEQPELE V QYQGRCKK TC RDVFCPG SST CVVDQT NNAY CVTCN RICPEPASSE QYLCG NDGV TYSSAC HLR KATCLLG RS IGLAYEGK C IKAKSCEDI QCTGGKKCLW DFKVGRGRC S LCDELCPD SK SDEPVCA SDNATYASEC AMK EAACSS GVLL EVKHS GSCN
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Follistatin / FST Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, 50mM sodium chloride, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Follistatin / FST Protein General Information | |
|---|---|
| Alternate Names | |
| Follistatin, FST, FS, AL033346 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FST |
| Entrez Gene ID | 10468 |
| Ensemble Gene ID | ENSG00000134363 |
| RefSeq Protein Accession(s) | NP_006341.1 |
| RefSeq mRNA Accession(s) | NM_006350.3, NM_013409.2 |
| UniProt ID(s) | P19883 |
| UniGene ID(s) | Hs.9914 |
| HGNC ID(s) | HGNC:3971 |
| COSMIC ID Link(s) | FST |
| KEGG Gene ID(s) | hsa:10468 |
| PharmGKB ID(s) | PA28388 |
| General Description of Recombinant Human Follistatin / FST Protein . | |
| Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-?) family members, such as activin, bone morphogenic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-?1. Follistatin functions as an antagonist by binding TGF-? family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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