PDF DatasheetMouse Follistatin / FST Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Follistatin / FST based upon sequence from: Mouse
Host: QP5428 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5428.
Bioactivity Data: Mouse Follistatin / FST induces MCP-11 cell proliferation (typical ED50 ? 1 ug/ml).
Monomer or Dimer: Monomer
Amino Acid Sequence: MGNCWLRQAK NGRCQVLYKT ELSKEECCST GRLSTSWTEE DVNDNTLFKW MIFNGGAPNC IPCKETCENV DCGPGKKCRM NKKNKPRCVC APDCSNITWK GPVCGLDGKT YRNECALLKA RCKEQPELEV QYQGKCKKTC RDVFCPGSST CVVDQTNNAY CVTCNRICPE PSSSEQYLCG NDGVTYSSAC HLRKATCLLG RSIGLAYEGK CIKAKSCEDI QCGGGKKCLW DSKVGRGRCS LCDELCPDSK SDEPVCASDN ATYASECAMK EAACSSGVLL EVKHSGSCN
Purity: Greater than 90 as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Mouse Follistatin / FST Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 5.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Mouse Follistatin / FST Protein General Information | |
|---|---|
| Alternate Names | |
| Follistatin, FST, FS, AL033346 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | FST |
| Entrez Gene ID | 14313 |
| RefSeq Protein Accession(s) | NP_001288302.1 |
| RefSeq mRNA Accession(s) | NM_001301373.1, NM_001301375.1, NM_008046.3 |
| UniProt ID(s) | P47931 |
| UniGene ID(s) | Mm.4913 |
| COSMIC ID Link(s) | FST |
| KEGG Gene ID(s) | mmu:14313 |
| General Description of Recombinant Mouse Follistatin / FST Protein . | |
| Follistatin is an autocrine, activin-binding protein that is ubiquitously expressed with highest expression levels being in the ovary and skin. Follistatin negatively regulates the signaling of transforming growth factor beta (TGF-?) family members, such as activin, bone morphogenic proteins (BMPs), myostatin, growth differentiation factor 11 (GDF-11), and TGF-?1. Follistatin functions as an antagonist by binding TGF-? family members to block interaction with their signaling receptors. Follistatin also inhibits the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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