PDF DatasheetHuman Galectin-3 / LGALS3 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Galectin-3 / LGALS3 based upon sequence from: Human
Host: QP5277 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5277.
Bioactivity Data: Activity of Galectin-3 was confirmed by measuring chemotaxis of human PBMCs. At concentrations greater than 1 ug/ml, Galectin-3 significantly enhanced migration of PBMCs compared to control.
Monomer or Dimer: Monomer
Amino Acid Sequence: MADNFSLHDA LSGSGNPNP Q GWPGAWGN QP AGAGGYP GAS YPGAYP GQAP PGAYP GQAPP GAYH GAPGAY PGA PAPGVYP GP PSGPGAYPSS GQPSAPGA Y PATGPYGAP AGPLIVPYNL PLPGGVVPR M LITILGTV KP NANRIAL DFQ RGNDVA FHFN PRFNE NNRRV IVCN TKLDNN WGR EERQSVF PF ESGKPFKIQV LVEPDHFK V AVNDAHLLQ YNHRVKKLNE ISKLGISGD I DLTSASYT MI
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Galectin-3 / LGALS3 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, 50mM sodium chloride, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Galectin-3 / LGALS3 Protein General Information | |
|---|---|
| Alternate Names | |
| Galectin-3, LGALS3 Protein, Low Endotoxin, GAL3, LGALS2, GALIG, L31, GALBP, CBP35, MAC2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | LGALS3 |
| Entrez Gene ID | 3958 |
| Ensemble Gene ID | ENSG00000131981 |
| RefSeq Protein Accession(s) | NP_002297.2 |
| RefSeq mRNA Accession(s) | NM_002306.3 |
| UniProt ID(s) | P17931 |
| UniGene ID(s) | Hs.531081 |
| HGNC ID(s) | HGNC:6563 |
| COSMIC ID Link(s) | LGALS3 |
| KEGG Gene ID(s) | hsa:3958 |
| PharmGKB ID(s) | PA30340 |
| General Description of Recombinant Human Galectin-3 / LGALS3 Protein . | |
| Galectin-3 belongs to the lectin family of carbohydrate binding proteins. Galectin-3 is expressed by a wide range of cell types including activated T cells, tumor cells, macrophages, osteoclasts, fibroblasts, and epithelial cells. Galectin-3 has specific binding affinity for beta-galactoside sugar moieties and has functional roles during development, innate immunity, cell apoptosis, and tumor metastasis. Galectin-3 is associated with cancer, heart failure, stroke, and inflammation. The amino acid sequences of human and mouse Galectin-3 proteins share 80% homology. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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