PDF DatasheetHuman GDF5 Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant GDF5 based upon sequence from: Human
Host: QP5375 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5375.
Bioactivity Data: Alkaline phosphatase activity in ATDC5 cells significantly induced by less than 1.2 ug/ml, or activity of at least 8.3 x 10^2 units/mg
,
(typical ED50 is ?
Monomer or Dimer: Dimer
Amino Acid Sequence: MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human GDF5 Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human GDF5 Protein General Information | |
|---|---|
| Alternate Names | |
| OS5, LAP4, BDA1C, BMP14, CDMP1, LAP-4, SYM1B, SYNS2, BMP-14, GDF-5 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | GDF5 |
| Entrez Gene ID | 8200 |
| Ensemble Gene ID | ENSG00000125965 |
| RefSeq Protein Accession(s) | NP_000548.2 |
| RefSeq mRNA Accession(s) | NM_000557.4, NM_001319138.1, XM_011529075.2 |
| UniProt ID(s) | P43026 |
| UniGene ID(s) | Hs.1573 |
| HGNC ID(s) | HGNC:4220 |
| COSMIC ID Link(s) | GDF5 |
| KEGG Gene ID(s) | hsa:8200 |
| PharmGKB ID(s) | PA28635 |
| General Description of Recombinant Human GDF5 Protein . | |
| Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenic protein (BMP) and transforming growth factor beta (TGF-?) families and functions to regulate cell proliferation and differentiation in embryonic and adult tissues. GDF-5 is expressed in the central nervous system and promotes the survival of dopaminergic neurons in animal models of Parkinson’s disease. GDF-5 is also important during chondrogenesis and chondrocyte differentiation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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