PDF DatasheetHuman IL-1 beta / IL1B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-1 beta / IL1B based upon sequence from: Human
Host: QP5290 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5290.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 12 pg/mL in the D10S cell proliferation assay. The bioactivity acceptance criteria is set at 8.3 x 10^7 units/mg.
Monomer or Dimer: Monomer
Amino Acid Sequence: MAPVRSLNCT LRDSQQKSLV MSGPYELKAL HLQGQDMEQQ VVFSMSFVQG EESNDKIPVA LGLKEKNLYL SCVLKDDKPT LQLESVDPKN YPKKKMEKRF VFNKIEINNK LEFESAQFPN WYISTSQAEN MPVFLGGTKG GQDITDFTMQ FVSS
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-1 beta / IL1B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL-1 beta / IL1B Protein General Information | |
|---|---|
| Alternate Names | |
| IL-1 beta, IL1B, IL-1, IL1-BETA, IL1F2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL1B |
| Entrez Gene ID | 3553 |
| Ensemble Gene ID | ENSG00000125538 |
| RefSeq Protein Accession(s) | NP_000567.1 |
| RefSeq mRNA Accession(s) | NM_000576.2 |
| UniProt ID(s) | P01584 |
| UniGene ID(s) | Hs.126256 |
| HGNC ID(s) | HGNC:5992 |
| COSMIC ID Link(s) | IL1B |
| KEGG Gene ID(s) | hsa:3553 |
| PharmGKB ID(s) | PA29808 |
| General Description of Recombinant Human IL-1 beta / IL1B Protein. | |
| Interleukin 1 beta (IL-1?) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1? signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1? and the independently regulated IL-1? protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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