PDF DatasheetHuman IL-1 beta / IL1B Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-1 beta / IL1B based upon sequence from: Human
Host: QP10307 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human IL-1 beta / IL1B, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10307.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of > 1.0 × 109 IU/mg.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
Purity: Greater than 97% as determined by SDS-PAGE and HPLC.
Reconstitution Instructions:
Concentration of Human IL-1 beta / IL1B Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 um filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human IL-1 beta / IL1B Protein General Information | |
|---|---|
| Alternate Names | |
| IL-1 beta; IL1B; IL-1; IL1-BETA; IL1F2 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL1B |
| Entrez Gene ID | 3553 |
| Ensemble Gene ID | ENSG00000125538 |
| RefSeq Protein Accession(s) | NP_000567.1 |
| RefSeq mRNA Accession(s) | NM_000576.2 |
| UniProt ID(s) | P01584 |
| UniGene ID(s) | Hs.126256 |
| HGNC ID(s) | HGNC:5992 |
| COSMIC ID Link(s) | IL1B |
| KEGG Gene ID(s) | hsa:3553 |
| PharmGKB ID(s) | PA29808 |
| General Description of Recombinant Human IL-1 beta / IL1B Protein. | |
| Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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