PDF DatasheetHuman IL-17AF Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-17AF based upon sequence from: Human
Host: QP5200 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5200.
Bioactivity Data: Production of IL-6 from mouse 3T3 cells was significantly induced by less than 50 ng/ml of Human IL-17AF, or activity of at least 2.0 x 10^4 units/mg
Monomer or Dimer: Dimer
Amino Acid Sequence: IL-17A:MIV KAGITIPRNP GCPNSEDKNF PRTVMVNLNI HNRNTNTNPK RSSDYYNRST SPWNLHRNED PERYPSVIWE AKCRHLGCIN ADGNVDYHMN SVPIQQEILV LRREPPHCPN SFRLEKILVS VGCTCVTPIV HHVAIL-17F :MRKIPKVGH TFFQKPESCP PVPGGSMKLD IGIINENQRV SMSRNIESRS TSPWNYTVTW DPNRYPSEVV QAQCRNLGCI NAQGKEDISM NSVPIQQETL VVRRKHQGCS VSFQLEKVLV TVGCTCVTPV IHHVQ
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human IL-17AF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL-17AF Protein General Information | |
|---|---|
| Alternate Names | |
| IL17, IL17A, CTLA-8, IL-17A, CTLA8, IL-17, IL17F, IL-17F, IL-17F, ML-1, ML1, CANDF6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL17 |
| Entrez Gene ID | 3605 |
| Ensemble Gene ID | ENSG00000112115 |
| RefSeq Protein Accession(s) | NP_002181.1 |
| RefSeq mRNA Accession(s) | NM_002190.2 |
| UniProt ID(s) | Q16552; Q96PD4 |
| UniGene ID(s) | Hs.41724 |
| HGNC ID(s) | HGNC:5981 |
| COSMIC ID Link(s) | IL17A |
| KEGG Gene ID(s) | hsa:3605 |
| PharmGKB ID(s) | PA29794 |
| General Description of Recombinant Human IL-17AF Protein . | |
| Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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