PDF DatasheetRat IL-17AF Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL-17AF based upon sequence from: Rat
Host: QP5206 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP5206.
Bioactivity Data: Rat IL-17AF induces IL-6 production in 3T3 cells as detected via ELISA (each lot is tested and typical ED50 is less than 20 ng/ml)
Monomer or Dimer: Dimer
Amino Acid Sequence: IL-17A:MAV LIPQSSVCPN AEANNFLQNV KVNLKVLNSL SSKASSRRPS DYLNRSTSPW TLSRNEDPDR YPSVIWEAQC RHQRCVNAEG KLDHHMNSVL IQQEILVLKR EPEKCPFTFR VEKMLVGVGC TCVSSIVRHA SIL-17F:MA RRNPKVGLSA LQKAGNCPPL EDNSVRVDIR IFNQNQGISV PRDFQNRSSS PWDYNITRDP DRFPSEIAEA QCRHSGCINA QGQEDGSMNS VPIQQEILVL RREPQGCSNS FRLEKMLIKV GCTCVTPIVH HAA
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Rat IL-17AF Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Rat IL-17AF Protein General Information | |
|---|---|
| Alternate Names | |
| IL17, IL17A, CTLA-8, IL-17A, CTLA8, IL-17, IL17F, IL-17F, IL-17F, ML-1, ML1, CANDF6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL17 |
| UniProt ID(s) | Q61453; Q5BJ95 |
| General Description of Recombinant Rat IL-17AF Protein . | |
| Interleukin 17AF (IL-17AF) is a heterodimer that is composed of the interleukin 17A (IL-17A) and interleukin 17F (IL-17F) members of the IL-17 family of cytokines. IL-17AF is produced by T helper 17 cells (Th17) following interleukin 23 (IL-23) stimulation. IL-17AF signals through the IL-17RA/IL-17RC receptor complex and functions to regulate inflammatory responses. IL-17AF induces chemokine and airway neutrophilia production, similar in function to IL-17A and IL-17F homodimers. In regard to these functions, IL-17AF is less active than the IL-17A homodimer and shows greater activity than the IL-17F homodimer. Human and rat IL-17AF are active on mouse cells. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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