PDF DatasheetHuman IL17F / IL-17F Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant IL17F / IL-17F based upon sequence from Human
Host: QP1158 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Bioactive
Application Notes: Please contact us for application specific information for QP1158.
Bioactivity Data: BioActivity: Shows bioactivity at a concentration of 100 ng/mL in the Production of IL-6 from mouse NIH 3T3 cells assay. The bioactivity acceptance criteria is set at 1 x 10^4 units/mg.
Monomer or Dimer: Dimer
Amino Acid Sequence: MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions: A Certificate of Analysis (CofA) will be sent along with the protein and will contain the proper reconstitution instructions.
Concentration of Human IL17F / IL-17F Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: Sterile filtered (0.22 um) solution containing 0.1% TFA
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human IL17F / IL-17F Protein General Information | |
|---|---|
| Alternate Names | |
| IL17F, IL-17F, IL-17F, ML-1, ML1, CANDF6 | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | IL17F |
| Entrez Gene ID | 112744 |
| Ensemble Gene ID | ENSG00000112116 |
| RefSeq Protein Accession(s) | NP_443104.1 |
| RefSeq mRNA Accession(s) | NM_052872.3, XM_011514276.1 |
| UniProt ID(s) | Q96PD4 |
| UniGene ID(s) | Hs.272295 |
| HGNC ID(s) | HGNC:16404 |
| COSMIC ID Link(s) | IL17F |
| KEGG Gene ID(s) | hsa:112744 |
| PharmGKB ID(s) | PA29800 |
| General Description of Recombinant Human IL17F / IL-17F Protein. | |
| Interleukin 17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin 6 (IL-6), interleukin 8 (IL-8), and granulocyte macrophage colony-stimulating factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin 2 (IL-2), monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor beta 1 (TGF-b1). | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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