PDF DatasheetHuman Pleiotrophin / PTN / HB-GAM Recombinant Protein Product Attributes
Product Type: Recombinant Protein
Recombinant Pleiotrophin / PTN / HB-GAM based upon sequence from: Human
Host: QP5365 protein expressed in E. coli.
Tag: Untagged
Recommended Applications: Immunogen, Protein Standard, Other Cell Biology Applications
Application Notes: Please contact us for application specific information for QP5365.
Bioactivity Data: Untested
Monomer or Dimer: Monomer
Amino Acid Sequence: MGKKEKPEKK VKKSDCGEWQ WSVCVPTSGD CGLGTREGTR TGAECKQTMK TQRCKIPCNW KKQFGAECKY QFQAWGECDL NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK KQEKMLD
Purity: Greater than 95% as determined by SDS-PAGE.
Reconstitution Instructions:
Concentration of Human Pleiotrophin / PTN / HB-GAM Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than or equal to 1.00 EUs/ug as determined by the LAL method.
Buffer: 10 mM sodium phosphate, pH 7.5
Storage Conditions: Store at -20C to -80C lyophilized. Guaranteed for 1 year at -80C reconstituted and 3 months at 4C reconstituted.
| Recombinant Human Pleiotrophin / PTN / HB-GAM Protein General Information | |
|---|---|
| Alternate Names | |
| Pleiotrophin, PTN, HB-GAM, HBGF-8, NEGF1, HBNF, OSF-1, HB-GAM, HBGF8, HBNF-1, HARP, HBBM | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTN |
| Entrez Gene ID | 5764 |
| Ensemble Gene ID | ENSG00000105894 |
| RefSeq Protein Accession(s) | NP_001308315.1 |
| RefSeq mRNA Accession(s) | NM_001321386.2, NM_001321387.2, NM_002825.6 |
| UniProt ID(s) | P21246 |
| UniGene ID(s) | Hs.371249 |
| HGNC ID(s) | HGNC:9630 |
| COSMIC ID Link(s) | PTN |
| KEGG Gene ID(s) | hsa:5764 |
| PharmGKB ID(s) | PA33974 |
| General Description of Recombinant Human Pleiotrophin / PTN / HB-GAM Protein . | |
| Pleiotrophin (PTN) is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. PTN is made by many tissues, but is predominantly secreted by nervous tissue during development. PTN induces neurite outgrowth and is involved in tumor growth and metastasis. PTN binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection. PNT can also binds the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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