PDF DatasheetHuman Pleiotrophin / PTN / HB-GAM Bioactive Protein Product Attributes
Product Type: Bioactive Protein
Recombinant Pleiotrophin / PTN / HB-GAM based upon sequence from: Human
Host: QP10421 protein expressed in E. coli.
Tag: Untagged
Protein Construction: A DNA sequence encoding the Human Pleiotrophin / PTN / HB-GAM, was expressed in the hosts and tags indicated. Please select your host/tag option, above.
Application Notes: Please contact us for application specific information for QP10421.
Bioactivity Data: Equivalent or superior bioactivity to competitors. Data available upon request. The biological activity was measured by its ability to enhance neurite outgrowth of E16E18 rat embryonic cortical neurons, when neurons were plated on 96 well culture plates that had been precoated with 100 ul/well of a solution of 510 ug/ml rHuPTN.
Full Length? Partial (see sequence information for more details).
Amino Acid Sequence: GKKEKPEKKV KKSDCGEWQW SVCVPTSGDC GLGTREGTRT GAECKQTMKT QRCKIPCNWK KQFGAECKYQ FQAWGECDLN TALKTRTGSL KRALHNAECQ KTVTISKPCG KLTKPKPQAE SKKKKKEGKK QEKMLD
Purity: Greater than 96% as determined by SDSPAGE and HPLC.
Reconstitution Instructions:
Concentration of Human Pleiotrophin / PTN / HB-GAM Protein: Lyophilized. Concentration determined by reconstitution volume.
Endotoxin Levels: Less than 1.0 EU/ug as determined by LAL method.
Buffer: 0.2 m filtered PBS, pH 7.4, lyophilized
Storage Conditions: Store at -20C to -80C.
| Recombinant Human Pleiotrophin / PTN / HB-GAM Protein General Information | |
|---|---|
| Alternate Names | |
| Pleiotrophin; PTN; HB-GAM; HBGF-8; NEGF1; HBNF; OSF-1; HB-GAM; HBGF8; HBNF-1; HARP; HBBM | |
| Curated Database and Bioinformatic Data | |
| Gene Symbol | PTN |
| Entrez Gene ID | 5764 |
| Ensemble Gene ID | ENSG00000105894 |
| RefSeq Protein Accession(s) | NP_001308315.1 |
| RefSeq mRNA Accession(s) | NM_001321386.2, NM_001321387.2, NM_002825.6 |
| UniProt ID(s) | P21246 |
| UniGene ID(s) | Hs.371249 |
| HGNC ID(s) | HGNC:9630 |
| COSMIC ID Link(s) | PTN |
| KEGG Gene ID(s) | hsa:5764 |
| PharmGKB ID(s) | PA33974 |
| General Description of Recombinant Human Pleiotrophin / PTN / HB-GAM Protein. | |
| Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. | |
Limitations and Performance Guarantee
This is a life science research product (for Research Use Only). This product is guaranteed to work for a period of two years when stored at -70C or colder, and one year when aliquoted and stored at -20C.
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